منابع مشابه
Zinc and Health: Current Status and Future Directions Zinc Homeostasis in Humans
Maintaining a constant state of cellular zinc nutrition, or homeostasis, is essential for normal function. In animals and humans, adjustments in zinc absorption and endogenous intestinal excretion are the primary means of maintaining zinc homeostasis. The adjustments in gastrointestinal zinc absorption and endogenous excretion are synergistic. Shifts in endogenous excretion appear to occur quic...
متن کاملZinc Toxicity in Humans
In dealing with zinc’s essentiality/toxicity (Dr. Jekyll and Mr. Hyde) duality, biological systems have developed the homeostatic ability to tightly regulate the zinc levels through a complicated framework for import and export, transport and distribution and sensing of zinc status to ensure that zinc does not participate in toxic reactions. In spite of the thousands of papers that have been pu...
متن کاملZinc homeostasis and neurodegenerative disorders
Zinc is an essential trace element, whose importance to the function of the central nervous system (CNS) is increasingly being appreciated. Alterations in zinc dyshomeostasis has been suggested as a key factor in the development of several neuropsychiatric disorders. In the CNS, zinc occurs in two forms: the first being tightly bound to proteins and, secondly, the free, cytoplasmic, or extracel...
متن کاملNicotianamine in zinc and iron homeostasis.
Transition metals such as Fe, Zn, and Cu are essential to plants but toxic in excess, and their accumulation is tightly regulated (Palmer and Guerinot, 2009). Offering exciting possibilities for applications such as bioremediation of contaminated sites and biofortification against nutritional deficiencies (e.g., of Zn; Palmgren et al., 2008), the molecular mechanisms of metal homeostasis are be...
متن کاملZnuA and zinc homeostasis in Pseudomonas aeruginosa
Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P. aeruginosa to colonise both environmental and host niches is the acquisition of zinc. Here we show that P. aeruginosa PAO1 acquires zinc via an ATP-binding cassette (ABC) permease in which ZnuA is the high affinity, zinc-specific binding protein....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2000
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/130.5.1360s